Kyasanur Forest Disease - causal agent and transmission cycle Image Transmission cycle and seasonal risk period for KFD KFD, also referred to as Monkey Fever, is a tick-borne viral haemorrhagic disease, which can be fatal to humans and other primates. The causal agent, Kyasanur Forest Disease Virus (family Flaviviridae, genus Flavivirus), is a member of the tick-borne encephalitis (TBE) complex. It is transmitted by a range of tick species, with Haemophysalis spinigera being considered the principal vector. A wide range of small rodents, monkeys and birds are thought to play a role in Kyasanur Forest Disease Virus (KFDV) transmission. Cattle are probably important hosts for adult H. spinigera ticks but develop neutralising antibodies against KFDV which suppress virus amplification. Humans, who contract KFD virus when bitten by an infected tick or by coming in contact with an infected animal, are considered dead-end hosts. This is because they cannot infect ticks nor other people with t
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